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A real research alert from this week
This is an actual email our subscribers received — new research about a treatment option for persistent acne.
Women with Persistent Acne Had a New Option That Worked as Well as Accutane with Fewer Side Effects
JAMA Dermatology · March 12, 2026
The Bottom Line
Low-dose spironolactone achieved comparable acne clearance rates to low-dose isotretinoin in women with persistent adult acne, with fewer reported side effects over 24 weeks.
What Happened
A double-blind randomized controlled trial enrolled 316 women aged 25-40 with moderate-to-severe persistent acne. Half received spironolactone and half received low-dose isotretinoin for 24 weeks. Both groups showed similar reductions in inflammatory lesions, but the spironolactone group reported significantly fewer side effects (18% vs. 41%).
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Curated from 75+ conditions across 15 medical specialties
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