Integrative transcriptomic meta-analysis reveals immune, synaptic, and non-coding RNA dysregulation in bipolar disorder across brain and blood.
What's New
A large transcriptomic meta-analysis identified immune, synaptic, and non-coding RNA dysregulation patterns across brain and blood tissues in bipolar disorder.
Detailed Summary
Eight independent meta-analyses integrated 19 postmortem brain datasets (917 samples) and 6 blood cohorts (638 samples) to identify differentially expressed genes in BD. Results revealed enrichment of genes involved in mitochondrial bioenergetics, oxidative stress, synaptic signaling, and neuroinflammation, along with several novel non-coding RNAs not previously linked to BD.
Study Population
Postmortem brain samples from 386 BD patients and 531 controls, and peripheral blood from 316 BD patients and 322 controls
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