Beyond Wrinkles: A Systematic Review and Meta-analysis of Off-Label Aesthetic Uses of Botulinum Neurotoxin.
What's New
A meta-analysis found that off-label aesthetic uses of botulinum toxin type A beyond wrinkle reduction were associated with 94% patient satisfaction and minimal complications.
Detailed Summary
A systematic review and meta-analysis of 38 studies (n=1,903) examined off-label aesthetic applications of botulinum toxin type A published between 2014 and 2024. Most interventions targeted the lower face (70.3%) for goals such as facial slimming, gummy smile correction, and contouring, with 75% of quantitatively measured outcomes showing sustained results at first follow-up.
Study Population
Adults aged 17 to 93 years (mean age 43.7), predominantly female (94.3%), receiving off-label aesthetic botulinum toxin type A (n=1,903)
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