Circulating saturated fatty acids and incident chronic kidney disease: a meta-analysis of de-novo prospective cohort investigations.
What's New
Higher circulating stearic acid (18:0) levels were associated with a lower risk of developing chronic kidney disease across 13 international cohorts.
Detailed Summary
A meta-analysis of 13 prospective cohorts from 9 countries (n=18,193) examined associations between circulating saturated fatty acids and incident CKD over a median 7.6-year follow-up. Higher stearic acid (18:0) concentrations were associated with lower CKD risk (RR 0.87; 95% CI, 0.80-0.95; P=0.003), while no significant associations were observed for other saturated fatty acids.
Study Population
18,193 adults with baseline eGFR >60 mL/min/1.73 m² across 13 cohorts in 9 countries; 2,554 developed CKD
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