Effect of walking exercise on liver enzymes in children with phenylketonuria and non-alcoholic fatty liver disease: A randomized controlled trial.

Medicina clinica·April 1, 2026·PMID: 41793924

What's New

An 8-week walking program was associated with significant improvements in liver enzymes and BMI in children with phenylketonuria and NAFLD.

Detailed Summary

A randomized controlled trial assigned 40 overweight or obese children (ages 9-12) with phenylketonuria and NAFLD to either an 8-week walking program (n=20) or a waitlist control (n=20). The exercise group demonstrated significant improvements in BMI, ALT, AST, ALP, GGT, and triglycerides, while no significant changes were observed in the control group.

Study Population

Overweight or obese children aged 9-12 with phenylketonuria and non-alcoholic fatty liver disease (n=40)

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