A Systematic Review and Meta-Analysis on the Induction of Confirmed Eosinophilic Esophagitis as a Side Effect of Allergen Immunotherapy: An EAACI Task Force Report.
What's New
Eosinophilic esophagitis was identified as a common side effect of oral immunotherapy for food allergies, occurring in approximately 2.3% of patients.
Detailed Summary
A systematic review and meta-analysis of 17 studies examined the incidence of confirmed eosinophilic esophagitis (EoE) during allergen immunotherapy. Across 15 studies of food desensitization (n=3,302), the pooled EoE incidence was 2.31% (95% CI 1.45-3.36%), typically diagnosed during the maintenance phase. Two studies of sublingual immunotherapy with aeroallergens (n=1,436) reported no EoE cases.
Study Population
Patients undergoing allergen immunotherapy for food or airborne allergies (n=4,738 across 17 studies)
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