Comparison of Semaglutide and Lifestyle Counselling for Weight Loss Using Multi-Site Electronic Health Records.
What's New
Semaglutide was associated with significantly higher rates of achieving 10% or greater weight loss compared to lifestyle counselling alone in adults with obesity.
Detailed Summary
A multi-site retrospective observational study using electronic health records compared semaglutide (minimum 16 weeks) to lifestyle counselling in propensity score-matched adults with obesity. Hazard ratios for achieving 10% weight loss favored semaglutide in both non-diabetic (HR 1.63; 95% CI, 1.32-2.01; p<0.001) and diabetic (HR 2.45; 95% CI, 1.47-4.09; p<0.001) populations.
Study Population
Adults with obesity, including 495 non-diabetic and 120 diabetic propensity score-matched participants per group (n=3,927 total eligible)
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