Combined high-intensity interval training and spirulina supplementation synergistically improve inflammatory and lipid-associated biomarkers in men with obesity.

Nutrition research (New York, N.Y.)·April 1, 2026·PMID: 41850008

What's New

Combined HIIT and spirulina supplementation was associated with greater changes in inflammatory and lipid-related biomarkers than either intervention alone in men with obesity.

Detailed Summary

A 12-week randomized trial assigned 64 men with obesity to control, spirulina (6 g/day), HIIT, or combined HIIT plus spirulina groups. The combined group demonstrated the most pronounced changes, including elevated IL-10 and ApoM, reduced IL-1β, increased S1P, and decreased Dectin-1 (P<.05), while individual interventions showed more limited effects.

Study Population

64 men with obesity (BMI ≥ 30 kg/m²), aged 20-35 years

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