Phosphodiesterase 4 Inhibitor Use in Pediatric Patients With Atopic Dermatitis: A Meta-Analysis of Randomized Controlled Trials.
What's New
Topical PDE4 inhibitors were associated with significantly higher treatment success rates compared to vehicle control in pediatric patients with mild-to-moderate atopic dermatitis.
Detailed Summary
A meta-analysis of 5 RCTs (n=1,877) found that topical PDE4 inhibitors were associated with higher Investigator Global Assessment response rates (OR 3.56; 95% CI, 2.09-6.04) and greater treatment success at weeks 2 and 4 compared to vehicle control, with no significant differences in adverse events.
Study Population
pediatric patients with mild-to-moderate atopic dermatitis (n=1,877 across 5 RCTs)
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