Impact of positive airway pressure therapy on pulmonary arterial pressures in obstructive sleep apnoea or obesity hypoventilation syndrome: a systematic review and meta-analysis.
What's New
Positive airway pressure therapy was associated with a mean reduction of ~6 mmHg in pulmonary arterial pressure in patients with severe OSA or obesity hypoventilation syndrome.
Detailed Summary
A systematic review and meta-analysis of 23 studies (n=733) found that PAP therapy was associated with a mean pulmonary arterial pressure reduction of 5.96 mmHg (95% CI 3.20-8.73; p<0.0001), with a larger reduction of 11.41 mmHg in those with baseline pulmonary hypertension. Heterogeneity was high (I²>85%), and certainty of evidence was rated low.
Study Population
Adults with mostly severe obstructive sleep apnoea (n=518) or obesity hypoventilation syndrome with concomitant OSA (n=215)
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