Pediatric Drug-Induced Sleep Endoscopy Directed Surgery Outcomes With Trisomy 21 Subgroup Comparison: A Meta-Analysis.
What's New
Drug-induced sleep endoscopy-directed surgery was associated with significant reductions in sleep apnea severity in children, with larger improvements observed in those with Trisomy 21.
Detailed Summary
A meta-analysis of 41 studies (n=3,404; 320 with Trisomy 21) found that drug-induced sleep endoscopy-directed surgery was associated with significant improvements in AHI (MD: 9.63; 95% CI: 7.54-11.73), obstructive AHI (MD: 11.46), and oxygen nadir (MD: -4.37; all P<.00001). The Trisomy 21 subgroup demonstrated more pronounced AHI reductions (MD: 14.78).
Study Population
pediatric patients aged ≤21 years with obstructive sleep apnea (n=3,404; 320 with Trisomy 21)
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